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Saint Spyridon is located in northern Manhattan on Wadsworth Avenue between 179th and 180th Street, three blocks east of the George Washington Bridge.
By car: It is easily accessible from the George Washington Bridge (exit 179th Street, follow to Wadsworth Avenue, make left), the West Side Highway (exit 179th Street, follow to Wadsworth Avenue, make left), the East River Drive (exit Amsterdam Avenue, 181st Street, follow to Wadsworth Avenue, make left) and the Cross Bronx Expressway (181st Street, last exit before bridge, follow to Wadsworth Avenue, make right).
By mass transit: Take the A train to 175th Street/George Washington Bridge Bus Terminal stop; walk two blocks east to Wadsworth Avenue. Take the #1 train to 181st Street stop. Walk one block west to Wadsworth Avenue.